Desoximetasone
A mid-to-high potency topical corticosteroid used to treat inflammatory skin conditions including psoriasis and atopic dermatitis by suppressing local immune responses. It is available in various formulations and should not be used on the face or in skin folds for extended periods.
Молекулярная масса
376,5000 g/mol
LogP
2,30
TPSA
74,60 Ų
Правило пяти Липинского
Соответствует
Терапевтические области
Механизм действия
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
2D Структура
Cite this structure
Embed this structure
SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO
InChI
InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
Molecular Formula
C22H29FO4
HBD / HBA
2 / 5
Вращаемые Связи
2
Тяжёлые Атомы
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Часто задаваемые вопросы
A mid-to-high potency topical corticosteroid used to treat inflammatory skin conditions including psoriasis and atopic dermatitis by suppressing local immune responses. It is available in various formulations and should not be used on the face or in skin folds for extended periods.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Desoximetasone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1766. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5311067. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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