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Deutetrabenazine

CHEMBL3137326 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
323.5 g/mol
LogP
2.9
Phase
4

A deuterium-substituted form of tetrabenazine that inhibits vesicular monoamine transporter 2 (VMAT2), reducing the amount of dopamine and other monoamines released at nerve terminals; used for chorea associated with Huntington's disease and tardive dyskinesia. The deuterium substitution slows metabolism, allowing twice-daily dosing.

Молекулярная масса

323,5000 g/mol

LogP

2,90

TPSA

38,80 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Schizophrenia Bipolar Disorder Major Depressive Disorder

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

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SMILES

                    
[2H]C([2H])([2H])Oc1cc2c(cc1OC([2H])([2H])[2H])C1CC(=O)C(CC(C)C)CN1CC2

                

                

                
                

                    
InChI

                    
InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/i3D3,4D3

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H27NO3

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
Вращаемые Связи

                        
4

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
23

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
A deuterium-substituted form of tetrabenazine that inhibits vesicular monoamine transporter 2 (VMAT2), reducing the amount of dopamine and other monoamines released at nerve terminals; used for chorea associated with Huntington's disease and tardive dyskinesia. The deuterium substitution slows metabolism, allowing twice-daily dosing.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Deutetrabenazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3137326.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 73442840.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.