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Dextrothyroxine

CHEMBL559 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
776.9 g/mol
LogP
2.4
Phase
4

The d-isomer of thyroxine (T4) that was used as a lipid-lowering agent in the 1960s but was withdrawn after clinical trials showed increased cardiovascular events and mortality. It lowered LDL cholesterol but caused thyrotoxicosis and other harmful effects.

Молекулярная масса

776,8700 g/mol

LogP

2,40

TPSA

92,80 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H11I4NO4

                    

                    
                    

                        
HBD / HBA

                        
3 / 5

                    

                    
                    

                        
Вращаемые Связи

                        
5

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
The d-isomer of thyroxine (T4) that was used as a lipid-lowering agent in the 1960s but was withdrawn after clinical trials showed increased cardiovascular events and mortality. It lowered LDL cholesterol but caused thyrotoxicosis and other harmful effects.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Dextrothyroxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL559.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 8730.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.