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Diphenhydramine Citrate

CHEMBL1201089 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
447.5 g/mol
LogP
—
Phase
4

A citrate salt form of diphenhydramine, an antihistamine used to treat allergies, motion sickness, and as a sleep aid. It works by blocking histamine receptors and has sedative properties.

Молекулярная масса

447,5000 g/mol

TPSA

145,00 Ų

Терапевтические области

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Cardiovascular Disease Respiratory Disease Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Asthma Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Infectious Disease Melanoma Oncology Gastroesophageal Reflux Disease Inflammatory Bowel Disease Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Lymphoma Hypertension Major Depressive Disorder Breast Cancer Atopic Dermatitis Chronic Pain Prostate Cancer Colorectal Cancer Leukemia

Механизм действия

First-generation H1 antihistamine with anticholinergic properties.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

First-generation H1 antihistamine with anticholinergic properties.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN(C)CCOC(c1ccccc1)c1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C17H21NO.C6H8O7/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-12,17H,13-14H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H29NO8

                    

                    
                    

                        
HBD / HBA

                        
4 / 9

                    

                    
                    

                        
Вращаемые Связи

                        
11

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
A citrate salt form of diphenhydramine, an antihistamine used to treat allergies, motion sickness, and as a sleep aid. It works by blocking histamine receptors and has sedative properties.

                        

                    

                    

                    

                    
                    

                        
                        

                            
First-generation H1 antihistamine with anticholinergic properties.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Diphenhydramine Citrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201089.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 174697.
                Chemical information database.
            
        
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Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.