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Dolutegravir Sodium

CHEMBL1213165 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
441.4 g/mol
LogP
—
Phase
4

The sodium salt form of dolutegravir, used in some pharmaceutical preparations of this integrase inhibitor for HIV treatment. As the parent drug dolutegravir, it prevents HIV from inserting its genetic material into human cell DNA. This salt form may be used to optimize solubility and bioavailability in specific formulations.

Молекулярная масса

441,4000 g/mol

TPSA

102,00 Ų

Терапевтические области

Cardiovascular Disease Rheumatoid Arthritis Osteoporosis Generalized Anxiety Disorder Insomnia Non-Alcoholic Fatty Liver Disease Obesity Malaria HIV/AIDS Hepatitis C Tuberculosis Heart Failure

Механизм действия

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c([O-])c3C(=O)N12.[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C20H19F2N3O5.Na/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22;/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28);/q;+1/p-1/t10-,15+;/m1./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C20H18F2N3NaO5

                    

                    
                    

                        
HBD / HBA

                        
1 / 8

                    

                    
                    

                        
Вращаемые Связи

                        
3

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
31

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
The sodium salt form of dolutegravir, used in some pharmaceutical preparations of this integrase inhibitor for HIV treatment. As the parent drug dolutegravir, it prevents HIV from inserting its genetic material into human cell DNA. This salt form may be used to optimize solubility and bioavailability in specific formulations.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral integrase, preventing the insertion of viral DNA into the host cell genome and blocking viral replication.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Dolutegravir Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1213165.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 46216142.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.