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Fezolinetant

CHEMBL3608680 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
358.4 g/mol
LogP
1.6
Phase
4

A non-hormonal medication that works by blocking neurokinin 3 receptors in the brain to reduce the frequency and severity of hot flashes in postmenopausal women. It provides relief without the use of estrogen, making it an option for those who cannot or prefer not to use hormone therapy.

Молекулярная масса

358,4000 g/mol

LogP

1,60

TPSA

105,00 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Cardiovascular Disease Breast Cancer Prostate Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H15FN6OS

                    

                    
                    

                        
HBD / HBA

                        
- / 7

                    

                    
                    

                        
Вращаемые Связи

                        
2

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
A non-hormonal medication that works by blocking neurokinin 3 receptors in the brain to reduce the frequency and severity of hot flashes in postmenopausal women. It provides relief without the use of estrogen, making it an option for those who cannot or prefer not to use hormone therapy.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Fezolinetant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3608680.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 117604931.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.