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Ivacaftor

CHEMBL2010601 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
392.5 g/mol
LogP
5.6
Phase
4

This CFTR potentiator is used to treat cystic fibrosis in patients with specific mutations (such as G551D) that cause the CFTR protein to be present but dysfunctional. It works by binding to the abnormal CFTR protein and keeping its chloride channel open for longer, improving airway hydration and mucus clearance. It was the first therapy to target the underlying genetic defect in cystic fibrosis.

Молекулярная масса

392,5000 g/mol

LogP

5,60

TPSA

78,40 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Chronic Obstructive Pulmonary Disease Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

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SMILES

                    
CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O

                

                

                
                

                    
InChI

                    
InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H28N2O3

                    

                    
                    

                        
HBD / HBA

                        
3 / 4

                    

                    
                    

                        
Вращаемые Связи

                        
4

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
This CFTR potentiator is used to treat cystic fibrosis in patients with specific mutations (such as G551D) that cause the CFTR protein to be present but dysfunctional. It works by binding to the abnormal CFTR protein and keeping its chloride channel open for longer, improving airway hydration and mucus clearance. It was the first therapy to target the underlying genetic defect in cystic fibrosis.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Ivacaftor is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2010601.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 16220172.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.