Levacetylleucine
This modified amino acid derivative has been investigated for the treatment of rare inherited neurological conditions called neuronal ceroid lipofuscinoses (Batten disease), where it may help stabilize cell membranes and reduce neurodegeneration. Research into its therapeutic potential for these devastating childhood diseases is ongoing.
Молекулярная масса
173,2100 g/mol
LogP
0,50
TPSA
66,40 Ų
Правило пяти Липинского
Соответствует
Механизм действия
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
2D Структура
Cite this structure
Embed this structure
SMILES
CC(=O)N[C@@H](CC(C)C)C(=O)O
InChI
InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1
Molecular Formula
C8H15NO3
HBD / HBA
2 / 3
Вращаемые Связи
4
Тяжёлые Атомы
12
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Часто задаваемые вопросы
This modified amino acid derivative has been investigated for the treatment of rare inherited neurological conditions called neuronal ceroid lipofuscinoses (Batten disease), where it may help stabilize cell membranes and reduce neurodegeneration. Research into its therapeutic potential for these devastating childhood diseases is ongoing.
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Yes, Levacetylleucine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL56021. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 70912. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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