Levocetirizine
The active R-enantiomer of cetirizine, a second-generation antihistamine used to treat allergic rhinitis, hives, and skin allergy symptoms. It provides relief from sneezing, runny nose, and itching with less sedation than older antihistamines.
Молекулярная масса
388,9000 g/mol
LogP
1,70
TPSA
53,00 Ų
Правило пяти Липинского
Соответствует
Терапевтические области
Механизм действия
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
2D Структура
Cite this structure
Embed this structure
SMILES
O=C(O)COCCN1CCN([C@H](c2ccccc2)c2ccc(Cl)cc2)CC1
InChI
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
Molecular Formula
C21H25ClN2O3
HBD / HBA
1 / 5
Вращаемые Связи
8
Тяжёлые Атомы
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Часто задаваемые вопросы
The active R-enantiomer of cetirizine, a second-generation antihistamine used to treat allergic rhinitis, hives, and skin allergy symptoms. It provides relief from sneezing, runny nose, and itching with less sedation than older antihistamines.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Levocetirizine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201191. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 1549000. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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