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Perphenazine

CHEMBL567 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
404.0 g/mol
LogP
4.2
Phase
4

Perphenazine is a typical antipsychotic belonging to the phenothiazine class that exerts its effects primarily by blocking dopamine D2 receptors in the mesolimbic and mesocortical pathways. It is used in the treatment of schizophrenia, bipolar disorder, and severe anxiety, and also possesses antiemetic properties due to its action on dopamine receptors in the chemoreceptor trigger zone.

Молекулярная масса

404,0000 g/mol

LogP

4,20

TPSA

55,30 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Stroke Obesity

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H26ClN3OS

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
Вращаемые Связи

                        
6

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Perphenazine is a typical antipsychotic belonging to the phenothiazine class that exerts its effects primarily by blocking dopamine D2 receptors in the mesolimbic and mesocortical pathways. It is used in the treatment of schizophrenia, bipolar disorder, and severe anxiety, and also possesses antiemetic properties due to its action on dopamine receptors in the chemoreceptor trigger zone.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Perphenazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL567.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4748.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.