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Phenformin

CHEMBL170988 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
205.3 g/mol
LogP
-0.8
Phase
4

Phenformin is a biguanide-class antidiabetic agent that lowers blood glucose primarily by inhibiting hepatic gluconeogenesis and improving peripheral insulin sensitivity through activation of AMP-activated protein kinase (AMPK). Although withdrawn from most markets due to a high risk of lactic acidosis, it has garnered renewed research interest as a potential antineoplastic agent, particularly in melanoma, through its effects on cellular metabolism and mTOR pathway inhibition.

Молекулярная масса

205,2600 g/mol

LogP

-0,80

TPSA

103,00 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Melanoma Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N=C(N)NC(=N)NCCc1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H15N5

                    

                    
                    

                        
HBD / HBA

                        
3 / 1

                    

                    
                    

                        
Вращаемые Связи

                        
4

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Phenformin is a biguanide-class antidiabetic agent that lowers blood glucose primarily by inhibiting hepatic gluconeogenesis and improving peripheral insulin sensitivity through activation of AMP-activated protein kinase (AMPK). Although withdrawn from most markets due to a high risk of lactic acidosis, it has garnered renewed research interest as a potential antineoplastic agent, particularly in melanoma, through its effects on cellular metabolism and mTOR pathway inhibition.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Phenformin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL170988.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 8249.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.