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Pralidoxime

CHEMBL1420 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
137.2 g/mol
LogP
1.0
Phase
4

Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.

Молекулярная масса

137,1600 g/mol

LogP

1,00

TPSA

36,50 Ų

Правило пяти Липинского

Соответствует

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[n+]1ccccc1C=NO

                

                

                
                

                    
InChI

                    
InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1

                

                

                

                    
                    

                        
Molecular Formula

                        
C7H9N2O+

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Вращаемые Связи

                        
1

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
10

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Pralidoxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1420.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 135398747.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.