Sulfadoxine
Sulfadoxine is a long-acting sulfonamide antibiotic used in combination with pyrimethamine (Fansidar) for the treatment and prevention of malaria caused by susceptible Plasmodium falciparum strains, particularly for intermittent preventive treatment in pregnancy and in malaria-endemic regions. The combination exploits sequential blockade of the folate synthesis pathway: sulfadoxine inhibits dihydropteroate synthase while pyrimethamine inhibits dihydrofolate reductase, providing synergistic antiparasitic activity. Resistance has limited its use in some geographic areas.
Молекулярная масса
310,3300 g/mol
LogP
0,70
TPSA
125,00 Ų
Правило пяти Липинского
Соответствует
Терапевтические области
Механизм действия
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.
2D Структура
Cite this structure
Embed this structure
SMILES
COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC
InChI
InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
Molecular Formula
C12H14N4O4S
HBD / HBA
2 / 8
Вращаемые Связи
5
Тяжёлые Атомы
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Часто задаваемые вопросы
Sulfadoxine is a long-acting sulfonamide antibiotic used in combination with pyrimethamine (Fansidar) for the treatment and prevention of malaria caused by susceptible Plasmodium falciparum strains, particularly for intermittent preventive treatment in pregnancy and in malaria-endemic regions. The combination exploits sequential blockade of the folate synthesis pathway: sulfadoxine inhibits dihydropteroate synthase while pyrimethamine inhibits dihydrofolate reductase, providing synergistic antiparasitic activity. Resistance has limited its use in some geographic areas.
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.
Yes, Sulfadoxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1539. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 17134. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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