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Sulfaphenazole

CHEMBL1109 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
314.4 g/mol
LogP
1.5
Phase
4

Sulfaphenazole is a sulfonamide antibacterial and potent inhibitor of cytochrome P450 2C9 (CYP2C9), used primarily as a research tool to characterize CYP2C9-mediated drug metabolism, and historically as an antibacterial agent for urinary tract infections. Its CYP2C9 inhibition causes clinically significant interactions with drugs metabolized by this enzyme including warfarin, tolbutamide, and phenytoin. The antibacterial mechanism involves inhibition of dihydropteroate synthase.

Молекулярная масса

314,4000 g/mol

LogP

1,50

TPSA

98,40 Ų

Правило пяти Липинского

Соответствует

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

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SMILES

                    
Nc1ccc(S(=O)(=O)Nc2ccnn2-c2ccccc2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H14N4O2S

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
Вращаемые Связи

                        
4

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Sulfaphenazole is a sulfonamide antibacterial and potent inhibitor of cytochrome P450 2C9 (CYP2C9), used primarily as a research tool to characterize CYP2C9-mediated drug metabolism, and historically as an antibacterial agent for urinary tract infections. Its CYP2C9 inhibition causes clinically significant interactions with drugs metabolized by this enzyme including warfarin, tolbutamide, and phenytoin. The antibacterial mechanism involves inhibition of dihydropteroate synthase.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Sulfaphenazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1109.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5335.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.