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Sulfoxone

CHEMBL1570 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
404.5 g/mol
LogP
1.2
Phase
4

Sulfoxone is a dapsone-related sulfone antibiotic used for the treatment of leprosy (Hansen's disease) in some formulations, acting through inhibition of bacterial dihydropteroate synthase similar to sulfonamides but with additional mechanisms involving disruption of folate cycle. As a sulfone antimycobacterial, it has been used as an alternative to dapsone in patients with dapsone intolerance. It is less widely used than dapsone for leprosy in current practice.

Молекулярная масса

404,5000 g/mol

LogP

1,20

TPSA

180,00 Ų

Правило пяти Липинского

Соответствует

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=S(O)CNc1ccc(S(=O)(=O)c2ccc(NCS(=O)O)cc2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C14H16N2O6S3/c17-23(18)9-15-11-1-5-13(6-2-11)25(21,22)14-7-3-12(4-8-14)16-10-24(19)20/h1-8,15-16H,9-10H2,(H,17,18)(H,19,20)

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H16N2O6S3

                    

                    
                    

                        
HBD / HBA

                        
4 / 10

                    

                    
                    

                        
Вращаемые Связи

                        
8

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Sulfoxone is a dapsone-related sulfone antibiotic used for the treatment of leprosy (Hansen's disease) in some formulations, acting through inhibition of bacterial dihydropteroate synthase similar to sulfonamides but with additional mechanisms involving disruption of folate cycle. As a sulfone antimycobacterial, it has been used as an alternative to dapsone in patients with dapsone intolerance. It is less widely used than dapsone for leprosy in current practice.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Sulfoxone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1570.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5351.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.