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Tamibarotene

CHEMBL25202 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
351.4 g/mol
LogP
5.4
Phase
4

Tamibarotene is a synthetic retinoic acid receptor alpha (RARα) agonist that promotes differentiation of leukemic blast cells, particularly in acute promyelocytic leukemia (APL) and is being studied for other hematologic malignancies. It is more selective for RARα than all-trans retinoic acid (ATRA), with potentially improved efficacy and tolerability in refractory APL. Research has also explored its role in Alzheimer's disease through modulation of neuroinflammatory pathways.

Молекулярная масса

351,4000 g/mol

LogP

5,40

TPSA

66,40 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Pancreatic Cancer Non-Small Cell Lung Cancer Alzheimer's Disease Systemic Lupus Erythematosus Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(C(=O)O)cc3)ccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H25NO3

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
Вращаемые Связи

                        
3

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Tamibarotene is a synthetic retinoic acid receptor alpha (RARα) agonist that promotes differentiation of leukemic blast cells, particularly in acute promyelocytic leukemia (APL) and is being studied for other hematologic malignancies. It is more selective for RARα than all-trans retinoic acid (ATRA), with potentially improved efficacy and tolerability in refractory APL. Research has also explored its role in Alzheimer's disease through modulation of neuroinflammatory pathways.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tamibarotene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL25202.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 108143.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.