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Thenalidine

CHEMBL2105458 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
286.4 g/mol
LogP
3.8
Phase
4

Thenalidine is a first-generation antihistamine with anticholinergic and anti-serotonin properties that blocks H1 histamine receptors, used historically for allergic conditions including urticaria and pruritus. It was withdrawn from markets due to serious hematological adverse effects including agranulocytosis and neutropenia. Its sedative properties were typical of first-generation antihistamines due to CNS histamine H1 receptor blockade.

Молекулярная масса

286,4000 g/mol

LogP

3,80

TPSA

34,70 Ų

Правило пяти Липинского

Соответствует

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN1CCC(N(Cc2cccs2)c2ccccc2)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H22N2S

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
Вращаемые Связи

                        
4

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Thenalidine is a first-generation antihistamine with anticholinergic and anti-serotonin properties that blocks H1 histamine receptors, used historically for allergic conditions including urticaria and pruritus. It was withdrawn from markets due to serious hematological adverse effects including agranulocytosis and neutropenia. Its sedative properties were typical of first-generation antihistamines due to CNS histamine H1 receptor blockade.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Thenalidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2105458.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 27901.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.