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Thiamylal

CHEMBL440 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
254.4 g/mol
LogP
3.2
Phase
4

Thiamylal is an ultra-short-acting barbiturate anesthetic that acts on GABA-A receptors to potentiate chloride ion influx, producing rapid induction of general anesthesia when administered intravenously. It was used as an induction agent for surgical anesthesia before the widespread adoption of propofol, offering rapid onset and recovery due to rapid redistribution from the brain to peripheral tissues. Its use has largely been replaced by propofol due to the latter's superior pharmacokinetic profile and recovery characteristics.

Молекулярная масса

254,3500 g/mol

LogP

3,20

TPSA

90,30 Ų

Правило пяти Липинского

Соответствует

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

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SMILES

                    
C=CCC1(C(C)CCC)C(=O)NC(=S)NC1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H18N2O2S

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
Вращаемые Связи

                        
5

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Thiamylal is an ultra-short-acting barbiturate anesthetic that acts on GABA-A receptors to potentiate chloride ion influx, producing rapid induction of general anesthesia when administered intravenously. It was used as an induction agent for surgical anesthesia before the widespread adoption of propofol, offering rapid onset and recovery due to rapid redistribution from the brain to peripheral tissues. Its use has largely been replaced by propofol due to the latter's superior pharmacokinetic profile and recovery characteristics.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Thiamylal is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL440.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3032285.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.