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Thiosulfuric Acid

CHEMBL1208642 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
114.2 g/mol
LogP
0.3
Phase
4

Thiosulfuric acid and its sodium salt (sodium thiosulfate) function as sulfur donors and reducing agents that react with cyanide to form non-toxic thiocyanate in the liver via the enzyme rhodanese, providing life-saving antidotal therapy for cyanide poisoning. Sodium thiosulfate is also used to reduce the nephrotoxicity of cisplatin in hyperthermic intraperitoneal chemotherapy, reduce calciphylaxis lesions, and as a topical antifungal. Its role in cancer care stems from its ability to neutralize cisplatin-induced nephrotoxicity without compromising antitumor efficacy when administered systemically after intraperitoneal cisplatin.

Молекулярная масса

114,1500 g/mol

LogP

0,30

TPSA

98,00 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Ovarian Cancer Lymphoma

Механизм действия

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=S(O)(O)=S

                

                

                
                

                    
InChI

                    
InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)

                

                

                

                    
                    

                        
Molecular Formula

                        
H2O3S2

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Вращаемые Связи

                        
0

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
5

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Thiosulfuric acid and its sodium salt (sodium thiosulfate) function as sulfur donors and reducing agents that react with cyanide to form non-toxic thiocyanate in the liver via the enzyme rhodanese, providing life-saving antidotal therapy for cyanide poisoning. Sodium thiosulfate is also used to reduce the nephrotoxicity of cisplatin in hyperthermic intraperitoneal chemotherapy, reduce calciphylaxis lesions, and as a topical antifungal. Its role in cancer care stems from its ability to neutralize cisplatin-induced nephrotoxicity without compromising antitumor efficacy when administered systemically …

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Thiosulfuric Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1208642.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 24478.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.