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Trimethaphan

CHEMBL1201329 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
365.5 g/mol
LogP
3.6
Phase
4

Trimethaphan is a ganglionic blocking agent that competitively antagonizes nicotinic acetylcholine receptors at both sympathetic and parasympathetic ganglia, producing rapid and controllable hypotension. It was used for controlled hypotension during surgery and for the management of hypertensive emergencies, particularly aortic dissection. Its short duration of action allowed for precise blood pressure control via intravenous infusion.

Молекулярная масса

365,5000 g/mol

LogP

3,60

TPSA

24,60 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Obesity Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

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SMILES

                    
O=C1N(Cc2ccccc2)C2C[S+]3CCCC3C2N1Cc1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H25N2OS+

                    

                    
                    

                        
HBD / HBA

                        
- / 1

                    

                    
                    

                        
Вращаемые Связи

                        
4

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Trimethaphan is a ganglionic blocking agent that competitively antagonizes nicotinic acetylcholine receptors at both sympathetic and parasympathetic ganglia, producing rapid and controllable hypotension. It was used for controlled hypotension during surgery and for the management of hypertensive emergencies, particularly aortic dissection. Its short duration of action allowed for precise blood pressure control via intravenous infusion.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Trimethaphan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201329.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 23576.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.