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Trospium

CHEMBL1888176 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
392.5 g/mol
LogP
4.4
Phase
4

Trospium is a quaternary ammonium antimuscarinic agent that blocks muscarinic M3 receptors in the detrusor muscle of the bladder, reducing involuntary contractions and increasing bladder capacity. It is used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency. Its quaternary structure limits CNS penetration, reducing cognitive side effects compared to tertiary antimuscarinics.

Молекулярная масса

392,5000 g/mol

LogP

4,40

TPSA

46,50 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Chronic Obstructive Pulmonary Disease Alzheimer's Disease Schizophrenia Bipolar Disorder Obesity

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(O[C@H]1C[C@H]2CC[C@@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23+

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H30NO3+

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
Вращаемые Связи

                        
5

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Trospium is a quaternary ammonium antimuscarinic agent that blocks muscarinic M3 receptors in the detrusor muscle of the bladder, reducing involuntary contractions and increasing bladder capacity. It is used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency. Its quaternary structure limits CNS penetration, reducing cognitive side effects compared to tertiary antimuscarinics.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Trospium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1888176.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5284632.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.