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Vilazodone

CHEMBL439849 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
441.5 g/mol
LogP
4.0
Phase
4

This antidepressant is used to treat major depressive disorder and works through a dual mechanism: it blocks serotonin reuptake (like SSRIs) and partially activates serotonin receptors (5-HT1A), which may improve its effectiveness and tolerability. It is taken once daily with food, as food significantly increases its absorption. Nausea and diarrhea are the most common side effects, particularly when starting treatment.

Молекулярная масса

441,5000 g/mol

LogP

4,00

TPSA

102,00 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Bipolar Disorder Generalized Anxiety Disorder Major Depressive Disorder

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

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SMILES

                    
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1

                

                

                
                

                    
InChI

                    
InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H27N5O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
Вращаемые Связи

                        
7

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
33

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
This antidepressant is used to treat major depressive disorder and works through a dual mechanism: it blocks serotonin reuptake (like SSRIs) and partially activates serotonin receptors (5-HT1A), which may improve its effectiveness and tolerability. It is taken once daily with food, as food significantly increases its absorption. Nausea and diarrhea are the most common side effects, particularly when starting treatment.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Vilazodone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL439849.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6918314.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.