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Zalcitabine

CHEMBL853 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
211.2 g/mol
LogP
-1.3
Phase
4

Zalcitabine (ddC, 2',3'-dideoxycytidine) is a nucleoside reverse transcriptase inhibitor (NRTI) that, after phosphorylation to its active triphosphate form, competitively inhibits HIV-1 reverse transcriptase and terminates nascent viral DNA chain elongation. It was one of the early antiretroviral agents approved for HIV/AIDS treatment. It is no longer clinically used due to its significant toxicity profile, including peripheral neuropathy and pancreatitis, and has been superseded by better-tolerated NRTIs.

Молекулярная масса

211,2200 g/mol

LogP

-1,30

TPSA

88,20 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Cardiovascular Disease Osteoporosis Generalized Anxiety Disorder Systemic Lupus Erythematosus Obesity Lymphoma Gout Malaria HIV/AIDS Hepatitis C Tuberculosis Colorectal Cancer Leukemia

Механизм действия

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H13N3O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
Вращаемые Связи

                        
2

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Zalcitabine (ddC, 2',3'-dideoxycytidine) is a nucleoside reverse transcriptase inhibitor (NRTI) that, after phosphorylation to its active triphosphate form, competitively inhibits HIV-1 reverse transcriptase and terminates nascent viral DNA chain elongation. It was one of the early antiretroviral agents approved for HIV/AIDS treatment. It is no longer clinically used due to its significant toxicity profile, including peripheral neuropathy and pancreatitis, and has been superseded by better-tolerated NRTIs.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Zalcitabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL853.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 24066.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.