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Zanamivir

CHEMBL222813 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
332.3 g/mol
LogP
-3.2
Phase
4

Zanamivir is a neuraminidase inhibitor that competitively blocks the influenza virus neuraminidase enzyme, preventing cleavage of sialic acid from host cell surface glycoproteins and inhibiting viral release, spread, and penetration of respiratory mucus. It is inhaled via the Diskhaler device for treatment and prevention of influenza A and B infections. Its topical inhalation route limits systemic bioavailability while delivering high drug concentrations to the respiratory tract.

Молекулярная масса

332,3100 g/mol

LogP

-3,20

TPSA

201,00 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Respiratory Disease Asthma Chronic Obstructive Pulmonary Disease

Механизм действия

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)OC(C(=O)O)=C[C@@H]1NC(=N)N

                

                

                
                

                    
InChI

                    
InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H20N4O7

                    

                    
                    

                        
HBD / HBA

                        
7 / 8

                    

                    
                    

                        
Вращаемые Связи

                        
6

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
23

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Zanamivir is a neuraminidase inhibitor that competitively blocks the influenza virus neuraminidase enzyme, preventing cleavage of sialic acid from host cell surface glycoproteins and inhibiting viral release, spread, and penetration of respiratory mucus. It is inhaled via the Diskhaler device for treatment and prevention of influenza A and B infections. Its topical inhalation route limits systemic bioavailability while delivering high drug concentrations to the respiratory tract.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Zanamivir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL222813.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60855.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.