Описание
Concurrent use of acyclovir and cyclosporine can increase nephrotoxicity risk, as both agents are renally cleared and individually nephrotoxic.
Механизм
Acyclovir causes crystalline nephropathy through renal tubular precipitation at high doses; cyclosporine independently causes afferent arteriolar vasoconstriction; combined renal insult is additive.
Клиническое значение
Case series in transplant recipients show elevated serum creatinine during acyclovir prophylaxis with cyclosporine; both drugs also compete for renal tubular secretion via OAT transporters.
Тактика ведения
Ensure adequate hydration during IV acyclovir; monitor serum creatinine and cyclosporine trough levels; consider dose reduction of acyclovir in renal impairment.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.