Описание
Alprazolam and gabapentin produce additive CNS depression, increasing the risk of sedation, dizziness, and psychomotor impairment.
Механизм
GABA-A potentiation (alprazolam) combined with alpha-2-delta calcium channel modulation and GABAergic enhancement (gabapentin) produces additive CNS inhibition.
Клиническое значение
Excessive sedation and ataxia are common with this combination; fall and fracture risk is substantially elevated.
Тактика ведения
Use caution; reduce doses of both agents and advise against activities requiring alertness until tolerance to sedation is established.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.