Описание
The combination of alprazolam and oxycodone carries an FDA boxed warning for profound CNS depression, respiratory depression, and death.
Механизм
Benzodiazepines potentiate GABA-A-mediated CNS inhibition; opioids activate mu-opioid receptors to reduce respiratory drive — additive CNS and respiratory depression occurs.
Клиническое значение
Real-world pharmacoepidemiological studies show a 3.86-fold increase in overdose mortality with concurrent benzodiazepine-opioid prescriptions.
Тактика ведения
Avoid combination when possible; if medically necessary, prescribe the lowest effective doses, limit duration, and provide naloxone.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.