Описание
Co-administration of alprazolam and quetiapine produces additive CNS depression with risk of profound sedation and respiratory compromise.
Механизм
Both agents have CNS depressant properties via distinct receptors: alprazolam via GABA-A and quetiapine via H1/D2/alpha-1 receptor blockade; additive inhibitory effects on CNS excitability occur.
Клиническое значение
The combination is associated with excess mortality in pharmacoepidemiological data, particularly in elderly patients with psychiatric illness.
Тактика ведения
Use with caution; monitor closely for excessive sedation and respiratory depression; avoid in patients with sleep apnea.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.