Описание
Fluoxetine is a potent CYP2D6 inhibitor that significantly increases aripiprazole plasma concentrations, enhancing both efficacy and adverse effects.
Механизм
Aripiprazole is metabolized by CYP2D6 to dehydro-aripiprazole (active); fluoxetine inhibition of CYP2D6 increases parent drug exposure significantly.
Клиническое значение
Aripiprazole AUC increases by approximately 112% with potent CYP2D6 inhibitors; akathisia, sedation, and weight gain may worsen.
Тактика ведения
Reduce aripiprazole dose to half when combined with fluoxetine or other potent CYP2D6 inhibitors; per FDA label.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.