Описание
The combination of aspirin and sertraline increases upper GI bleeding risk through synergistic antiplatelet and platelet serotonin depletion effects.
Механизм
Aspirin impairs COX-1–mediated platelet activation; sertraline depletes platelet serotonin stores, reducing platelet aggregation response. Both impair primary hemostasis.
Клиническое значение
The absolute increase in GI bleed risk is approximately 3.6 per 1000 patient-years when SSRIs are added to aspirin, based on large cohort data.
Тактика ведения
Add a PPI; use the lowest effective doses; monitor for GI symptoms and frank bleeding, particularly in patients over 65 years.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.