Описание
Azithromycin and ondansetron both prolong the cardiac QT interval; their combination substantially increases the risk of torsades de pointes.
Механизм
Both drugs are hERG channel blockers; additive reduction in IKr potassium current prolongs the QTc interval in a dose-dependent, additive fashion.
Клиническое значение
FDA issued safety communications for both drugs individually; combined use has been associated with arrhythmia events in case reports.
Тактика ведения
Avoid concurrent use; select alternative antiemetics or antibiotics; monitor ECG and correct hypokalemia and hypomagnesemia if combination is essential.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.