Описание
Ranitidine may reduce the absorption rate of cephalexin by raising gastric pH, but overall bioavailability is not substantially altered, making this interaction clinically insignificant.
Механизм
Acid suppression by ranitidine can alter the dissolution rate of cephalexin capsules, potentially delaying Tmax; total absorption (AUC) is largely unaffected.
Клиническое значение
No clinically meaningful reduction in cephalexin efficacy has been documented; the interaction is considered theoretical.
Тактика ведения
No dose adjustment or timing modification is required.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.