Описание
Diazepam and diphenhydramine produce additive CNS depression, with risk of profound sedation, cognitive impairment, and falls.
Механизм
Diazepam potentiates GABA-A inhibition; diphenhydramine blocks H1 receptors causing sedation and has anticholinergic effects — additive CNS depression occurs.
Клиническое значение
Particularly hazardous in elderly patients; both drugs appear on the Beers Criteria as potentially inappropriate in older adults.
Тактика ведения
Avoid combination especially in elderly; use non-sedating antihistamines and minimize benzodiazepine duration.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.