Описание
Valsartan may slightly increase digoxin plasma levels by reducing its renal clearance; the interaction is generally modest.
Механизм
Angiotensin II promotes renal tubular secretion of digoxin; ARB-mediated angiotensin II blockade may reduce this secretion, marginally raising digoxin levels.
Клиническое значение
Small increase in digoxin exposure; rarely clinically significant unless patient is already at the upper end of the therapeutic range.
Тактика ведения
Monitor digoxin levels when initiating valsartan in digitalized patients; adjust dose if levels exceed 1.2 ng/mL.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.