Описание
Diphenhydramine potentiates morphine-induced CNS and respiratory depression and may increase the risk of fatal overdose.
Механизм
H1 receptor blockade and anticholinergic effects of diphenhydramine are additive to mu-opioid receptor-mediated CNS and respiratory depression.
Клиническое значение
The combination carries significant risk of profound sedation, respiratory compromise, and death, particularly at higher doses.
Тактика ведения
Use non-sedating antihistamines; if diphenhydramine is needed, monitor closely for excessive sedation and reduce opioid dose.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.