Описание
Fluoxetine is a potent CYP2D6 inhibitor that substantially increases duloxetine plasma levels, while both agents also increase serotonin syndrome risk.
Механизм
Fluoxetine inhibits CYP2D6, reducing duloxetine clearance and raising systemic exposure; additive SERT inhibition further increases serotonergic tone.
Клиническое значение
Pharmacokinetic interaction can increase duloxetine AUC several-fold, increasing side effects; combined serotonergic effect also raises toxicity risk.
Тактика ведения
Avoid concurrent use; if switching, allow a 5-week washout after fluoxetine before starting duloxetine.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.