Описание
Combining two SSRIs is generally contraindicated due to markedly elevated serotonin syndrome risk and no additional therapeutic benefit.
Механизм
Both agents inhibit SERT-mediated serotonin reuptake; concurrent use produces additive serotonin accumulation in central synapses.
Клиническое значение
Dual SSRI therapy provides no clinical advantage over monotherapy and substantially raises serotonin toxicity risk.
Тактика ведения
Avoid concurrent use; when switching SSRIs, allow an appropriate washout period (5 half-lives of the discontinued drug).
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.