Описание
Co-prescribing two SSRIs leads to additive serotonin excess with no therapeutic benefit and high risk of serotonin syndrome.
Механизм
Both escitalopram and sertraline inhibit the serotonin transporter (SERT); concurrent use causes additive blockade and serotonin accumulation.
Клиническое значение
Combination offers no evidence-based advantage and increases serotonin toxicity risk significantly.
Тактика ведения
Contraindicated; switch fully from one SSRI to another with appropriate washout period rather than combining.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.