Описание
Combining ibuprofen with corticosteroids dramatically increases the risk of GI ulcers and hemorrhage beyond the risk of either agent alone.
Механизм
Ibuprofen impairs prostaglandin-mediated gastroprotection (mucus, bicarb, blood flow); corticosteroids independently impair mucosal defense and healing. The combination is synergistically ulcerogenic.
Клиническое значение
The risk of GI ulceration is increased ~15-fold with combined NSAID + corticosteroid compared with neither drug.
Тактика ведения
Avoid combination; use acetaminophen for analgesia. If co-administration is essential, prescribe gastroprotective therapy (PPI) and use the lowest effective doses.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.