Описание
Naproxen combined with sertraline increases the risk of upper GI bleeding through complementary impairment of platelet function and gastric mucosal defense.
Механизм
Sertraline depletes platelet serotonin stores, reducing aggregation; naproxen inhibits COX-1 and damages gastric mucosa. The combination amplifies GI hemorrhagic risk.
Клиническое значение
Epidemiological studies show a 12–15-fold increase in upper GI bleed risk with NSAID + SSRI combined.
Тактика ведения
Co-prescribe a PPI; prefer acetaminophen over NSAIDs in patients on SSRIs; educate patient about GI bleeding warning signs.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.