Описание
Sertraline and tramadol together significantly increase serotonergic tone, posing a clinically meaningful risk of serotonin syndrome.
Механизм
Sertraline inhibits SERT-mediated serotonin reuptake; tramadol also inhibits serotonin and norepinephrine reuptake, resulting in additive serotonin accumulation in CNS synapses.
Клиническое значение
Multiple published case reports and regulatory warnings document serotonin syndrome with this combination.
Тактика ведения
Avoid concurrent use; if tramadol is unavoidable, start at the lowest dose, titrate slowly, and monitor closely for signs of serotonin toxicity.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.