Atezolizumab vs Osimertinib

## Atezolizumab vs Osimertinib: Overview

This comparison examines the pharmacological differences between **Atezolizumab** and **Osimertinib**.

## Mechanism of Action

**Atezolizumab**: Fully human anti-PD-L1 IgG1 monoclonal antibody blocking PD-L1 interaction with PD-1 and B7.1.

**Osimertinib**: Third-generation irreversible EGFR TKI targeting T790M resistance mutation and activating mutations.

## Pharmacokinetics

**Half-life**: Atezolizumab — 27 days; Osimertinib — 48 hours.

## Chemical Properties

**Molecular Formula**: Atezolizumab — N/A; Osimertinib — C28H33N7O2.

**Molecular Weight**: Atezolizumab — N/A; Osimertinib — 499.6050 g/mol.

**Type**: Atezolizumab — Antibody; Osimertinib — Small molecule.