Diphenhydramine vs Duloxetine

## Diphenhydramine vs Duloxetine: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Duloxetine**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Duloxetine — 12 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Duloxetine — C18H19NOS.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Duloxetine — 297.4150 g/mol.

**Type**: Diphenhydramine — Small molecule; Duloxetine — Small molecule.