Hydroxychloroquine vs Tofacitinib

## Hydroxychloroquine vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Hydroxychloroquine** and **Tofacitinib**.

## Mechanism of Action

**Hydroxychloroquine**: Accumulates in lysosomes raising pH; inhibits toll-like receptor signaling.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Hydroxychloroquine — 40-50 days; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Hydroxychloroquine — C18H26ClN3O; Tofacitinib — C16H20N6O.

**Molecular Weight**: Hydroxychloroquine — 335.8720 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Hydroxychloroquine — Small molecule; Tofacitinib — Small molecule.