Ipilimumab vs Tacrolimus

## Ipilimumab vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Ipilimumab** and **Tacrolimus**.

## Mechanism of Action

**Ipilimumab**: Fully human anti-CTLA-4 IgG1 monoclonal antibody that blocks CTLA-4 inhibitory signaling.

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Ipilimumab — 14.7 days; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Ipilimumab — N/A; Tacrolimus — C44H69NO12.

**Molecular Weight**: Ipilimumab — N/A; Tacrolimus — 804.0180 g/mol.

**Type**: Ipilimumab — Antibody; Tacrolimus — Small molecule.