Metformin vs Tolbutamide

## Metformin vs Tolbutamide: Overview

This comparison examines the pharmacological differences between **Metformin** and **Tolbutamide**.

## Mechanism of Action

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

## Pharmacokinetics

**Half-life**: Metformin — 4-9 hours; Tolbutamide — N/A.

## Chemical Properties

**Molecular Formula**: Metformin — C4H11N5; Tolbutamide — N/A.

**Molecular Weight**: Metformin — 129.1640 g/mol; Tolbutamide — N/A.

**Type**: Metformin — Small molecule; Tolbutamide — Small molecule.