Methotrexate vs Trimethoprim

## Methotrexate vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Methotrexate** and **Trimethoprim**.

## Mechanism of Action

**Methotrexate**: Dihydrofolate reductase inhibitor.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Methotrexate — 3-10 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Methotrexate — C20H22N8O5; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Methotrexate — 454.4400 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Methotrexate — Small molecule; Trimethoprim — Small molecule.