Sacubitril-Valsartan vs Valsartan

## Sacubitril-Valsartan vs Valsartan: Overview

This comparison examines the pharmacological differences between **Sacubitril-Valsartan** and **Valsartan**.

## Mechanism of Action

**Sacubitril-Valsartan**: Angiotensin receptor-neprilysin inhibitor (ARNI) combining neprilysin inhibition with AT1 receptor blockade.

**Valsartan**: Angiotensin II type 1 receptor blocker.

## Pharmacokinetics

**Half-life**: Sacubitril-Valsartan — 11.5 hours; Valsartan — 6 hours.

## Chemical Properties

**Molecular Formula**: Sacubitril-Valsartan — C24H29N2O5; Valsartan — C24H29N5O3.

**Molecular Weight**: Sacubitril-Valsartan — 414.5010 g/mol; Valsartan — 435.5190 g/mol.

**Type**: Sacubitril-Valsartan — Small molecule; Valsartan — Small molecule.