Tacrolimus vs Tofacitinib

## Tacrolimus vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Tacrolimus** and **Tofacitinib**.

## Mechanism of Action

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Tacrolimus — 12 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Tacrolimus — C44H69NO12; Tofacitinib — C16H20N6O.

**Molecular Weight**: Tacrolimus — 804.0180 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Tacrolimus — Small molecule; Tofacitinib — Small molecule.