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Acoramidis

CHEMBL3940890 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
292.3 g/mol
LogP
2.9
Phase
4

A small molecule medication that stabilizes the transthyretin protein, preventing it from misfolding and clumping into harmful amyloid deposits in the heart and nerves. It is used to treat transthyretin amyloid cardiomyopathy, a progressive condition in which amyloid buildup weakens and stiffens the heart muscle. Taken orally three times daily, it has been shown to slow the progression of the disease and reduce hospitalizations for heart failure.

น้ำหนักโมเลกุล

292.3000 g/mol

LogP

2.90

TPSA

75.20 Ų

Lipinski RO5

ผ่าน

กลไกการออกฤทธิ์

Stabilizes the transthyretin (TTR) protein tetramer, preventing its dissociation into monomers that misfold and aggregate into amyloid fibrils in cardiac tissue.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Stabilizes the transthyretin (TTR) protein tetramer, preventing its dissociation into monomers that misfold and aggregate into amyloid fibrils in cardiac tissue.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1n[nH]c(C)c1CCCOc1cc(C(=O)O)ccc1F

                

                

                
                

                    
InChI

                    
InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H17FN2O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
พันธะที่หมุนได้

                        
6

                    

                    
                    
                    

                        
อะตอมหนัก

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
A small molecule medication that stabilizes the transthyretin protein, preventing it from misfolding and clumping into harmful amyloid deposits in the heart and nerves. It is used to treat transthyretin amyloid cardiomyopathy, a progressive condition in which amyloid buildup weakens and stiffens the heart muscle. Taken orally three times daily, it has been shown to slow the progression of the disease and reduce hospitalizations for heart failure.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Stabilizes the transthyretin (TTR) protein tetramer, preventing its dissociation into monomers that misfold and aggregate into amyloid fibrils in cardiac tissue.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Acoramidis is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3940890.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 71464713.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.